Functional studies of intimin in vivo and ex vivo: implications for host specificity and tissue tropism

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Functional studies of intimin in vivo and ex vivo: implications for host specificity and tissue tropism

Intimin is an outer-membrane adhesin that is essential for colonization of the host gastrointestinal tract by attaching and effacing pathogens including enteropathogenic Escherichia coli (EPEC), enterohaemorrhagic E. coli (EHEC) and Citrobacter rodentium (CR). The N-terminus of intimin from the different strains is highly conserved while the C-terminus, which harnesses the active receptor-bindi...

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ژورنال

عنوان ژورنال: Microbiology

سال: 2007

ISSN: 1350-0872,1465-2080

DOI: 10.1099/mic.0.2006/003467-0